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If all the variances λi are identical and equal to σ2, the best equivariant estimators of β and b are given by ˆ t 1 t ˆ (p q 2)σ2 β (Z Z) Z x and b s2with s2 pi1(xi ziβˆ)2. Jr. ) The practical experimenters way to deal with this will include randomizing the order of treatment given to the patient. The development of the graphic adventure genre, associated early on with evermore vivid depictions of settings and characters through the integration of elabo- rate bitmaps, is the first major manifestation of these ambitions.
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